Altered Gene Expression Encoding Cytochines, Grow Factors and Cell Cycle Regulators in the Endometrium of Women with Chronic Endometritis
نویسندگان
چکیده
To evaluate the expression of genes encoding cytokines, grow factors and cell cycle regulators in proliferative endometrium women with chronic endometritis (CE) compared to controls. We performed a case-control study on seven CE as diagnosed by hysteroscopy histology (Cases) six without (Controls). All underwent diagnostic plus endometrial biopsy during mid-proliferative phase menstrual cycle. Endometrial samples were divided into two different aliquots for histological molecular analyses. The profile 16 proteins involved inflammatory process, proliferation regulation/apoptosis was assessed using high-throughput qPCR. Study endpoints between-group differences VEGF A, B, C, EGF, TNF, TGF B1, IFNG, TP73, TP73L, BAXva, CDC2, CDC2va, CCND3, CCNB1, BAX IL12. RESULTS: CCNB1 significantly overexpressed controls, while IL12 had similar between groups. In CE, we found an altered inflammatory, proliferation, apoptosis processes. dominance anti-apoptotic activity may potentially promote development polyps hyperplastic lesions.
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ژورنال
عنوان ژورنال: Diagnostics
سال: 2021
ISSN: ['2075-4418']
DOI: https://doi.org/10.3390/diagnostics11030471